Schedule • CSB Group Meeting

Accademia delle Scienze dell'Istituto di Bologna — Via Zamboni, 31, Bologna · Sala Ulisse

Programme · June 16, 2026

Session 1: Systems Biology, Metabolic & Clinical Translation Chair: Lara Console (University of Calabria)

Time	Speaker	Title
10:00–10:10	Chair / Organizer	Opening Remarks
10:10–10:25	Matteo Turati University of Milano-Bicocca	Stability-Aware Parameter Identification for Generalized Lotka-Volterra Models
10:25–10:40	Pasquale Palumbo University of Milano-Bicocca	Expanding the iMeGroCy Framework: Dynamic Nutrient Responses, Ribosome Biogenesis Modules, and Mammalian Cell Modeling
10:40–10:55	Bruno Giovanni Galuzzi CNR, Milano	Unveiling Spatial and Pathway-Level Metabolic Programs in Cancer Through Transcriptome-Guided Flux Analysis
10:55–11:10	Anna Visibelli University of Siena	Quantifying the Functional Gap in Alkaptonuria Through Machine Learning and Clinical Data Integration
☕ Coffee Break: 11:10–11:40

Session 2: Molecular Mechanisms, Dynamics & Metabolic Modeling Chair: Giulia Babbi (University of Bologna)

Time	Speaker	Title
11:40–11:55	Alfonso Trezza University of Siena	Architecture and Dynamics of a Supramolecular Oxygen Transport System in Human Homogentisate 1,2-Dioxygenase
11:55–12:10	Miriana Quaranta Sapienza University of Rome	SLC25A38 Preferentially Transports Pyridoxal 5′-Phosphate over Glycine: A Computational Study
12:10–12:25	Lara Console University of Calabria	A Combined Computational Modeling and Proteoliposome Nanotechnology to Accelerate Ligand Discovery for Solute Carrier Transporters
12:25–12:40	Giovanni Merici University of Parma	Integrating Coevolutionary Analysis, Structural Prediction, and Molecular Dynamics for Complex Discovery
12:40–12:55	Davide Bianchi University of Milan	Computational Dissection of the Cooperative Effects of Fc Glycosylation and Light Chain Isotype on IgG1::FcγRIIIa Recognition
🍽️ Lunch Break: 13:00–14:00

Session 3: Structural Bioinformatics & Predictive Tools Chair: Maria Cristina Aspromonte (University of Padova)

Time	Speaker	Title
14:00–14:15	Matteo Manfredi University of Bologna	Alpha&ESM hFolds: An Updated Database for the Comparison and Functional Annotation of Predicted Structural Models for the Human Proteome
14:15–14:30	Veronica Morea CNR Roma	A Consensus-Based Framework for the Identification of Structurally Conserved Protein Regions
14:30–14:45	Damiano Parrone Sapienza Università di Roma	A Prediction Tool for the Inference of Rare Misfolding Variants Responsive to Pharmacological Chaperones
14:45–15:00	Alessandra Robello Sapienza University of Rome	Computational Framework for the Design of Second-Generation Pharmacochaperones Targeting Allosteric Pockets
15:00–15:15	Sol Clara Begue University of Padua.	Towards RING 5.0: An Updated Tool for the Analysis of Protein Structures Through Residue Interaction Networks
☕ Coffee Break: 15:15–15:45

Session 4: Gene and Variant Prioritization for Genome Interpretation Chair: Alfonso Trezza (University of Siena)

Time	Speaker	Title
15:45–16:00	Alessia Pinto University of Rome "Tor Vergata"	Complex Genotype–Phenotype Correlations in Autism Spectrum Disorder: A Systems Biology Approach
16:00–16:15	Chiara Rivi University of Bologna	Mapping the Neurodevelopmental Disorder Gene Landscape: From Data Integration to Multi-Ontology Candidate Prioritization
16:15–16:30	Maria Cristina Aspromonte University of Padova	Localized Missense Constraint Reveals Functional Regions in Intrinsically Disordered Proteins Associated with Neurodevelopmental Disorders
16:30–16:45	Giulia Babbi University of Bologna	Bioinformatic Sweeties: A Suite of User-Friendly Bioinformatic Tools for Characterizing Proteins and Their Variants
16:45–16:55	Chair / Organizer	Closing Remarks

📌 Final detailed schedule — all speakers and titles confirmed.